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This article investigates the application of the CFB (CDIO – Flipped classroom - Blended learning) model in teaching Economic Statistics at the College of Economics, Vinh University. The integration of the CDIO framework emphasizes the application-driven approach, while the flipped classroom method redefines traditional learning dynamics by shifting content delivery outside of class time. Blended learning further enriches the educational experience through a seamless combination of online and face-to-face interactions. The research article makes a specific process for designing a lesson plan applying the CFB model in Economic Statistics at College of Economics, Vinh University.