Bài báo khoa học

Aiming to isolate new metabolites from the Alpinia genus, we wish to report the chemical constituents from the rhizomes of A. lepharocalyx K. Schum. and their anti-inflammatory activity. The plants of Alpinia genus have been used in traditional medicine in Vietnam. They are perennial plants used for many decades to treat several ailments including pain, cold, stomach-ache or inflammation. The dried material was extracted using the maceration with methanol at a room temperature. The methanol extract was applied to column hromatograph to obtain purified compounds. The compounds were tested for their antiinflammatory activity. Chemical constituents from rhizomes of A. blepharocalyx showed six including 4-hydroxy-2-methoxyphenoxy-β-D-{3’’-O-[4-hydroxy-3’-methoxy (benzoate)]}-glucopyranoside (1), desmethoxyyangonin (2), trans-resveratrol (3), zerumbone (4), isdemethoxycurcumin (5), and demethoxycurcumin (6). These compounds may have potentials as anti-inflammatory agents. Compounds 1–6 showed moderate inhibitory activities with IC50 values of 7.66–14.06 μM. The rhizomes of A. blepharocalyx included bioactive compounds that could be used in food supplements as a natural anti-inflammatory agent.