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CoV (coronavirus) is a group of agents capable of infecting HIV into facilities and causing many symptoms of respiratory, palm, liver and neurological diseases... CoV is the 7th virus in the group of coronar viruses known known to have the ability to collect data on users. CoVs are divided into four genera: alpha-CoV, beta-CoV, gamma-CoV and delta-CoV. In particular, SAR-CoV-2 is the virus that has caused the COVID-19 pandemic (coronavirus disease 2019) belonging to the beta-CoV genus, beta-CoV 2b group, with a genome of positive linear single-stranded RNA (+ssRNA). size 30kb distance. So far, a series of genetic mutations in coronavirus-2 have occurred since the virus emerged. Success of mutations in the random replication of viral vectors A notable situation is that once novel mutations appear, mutants carrying them become more and more numerous. In fact, most of the mutations that occur in the SARS-CoV-2 genome do not significantly affect the spread and virulence of the virus, as well as the disease progression. However, there are many new mutations that appear that can help increase the speed of virus infection or reduce/lose the effectiveness of the vaccines being used. The virus can escape from the immune system. GENE MUTATIONS IN SAR-COV- 2 and their variants human body fluids formed as a result of previous vaccination. This article addresses the emergence and proliferation of mutations in SARS-CoV-2 and their variations to help readers gain more comprehensive and up-to-date information about SARS-CoV-2