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The Limonoids and Other Constituents from the Fruits of Melia azedarach and Their Biological Activity
Authors: 57. Tuan, N. N., Kuo, P. C., Hoang, V. D., Hien, V. T., Quang, L. D., Hieu, T. T., Li, Y. C., Thanh, N. T., Wu, T. S., Thang, T. D
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Records of Natural Products
: 16(4)     : 307-315
: https://doi.org/10.25135/rnp.277.21.06.2097
: 1213_57_.pdf
Publishing year: 2/2022
Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach. The structure of 1 was established by various spectroscopic and mass spectrometric analyses. Among the eleven isolated compounds, trichilinin G (1) and meliatoxin B1 (2) were examined for their antifungal activity against Fusarium oxysporum, Magnaporthe grisea, Phytophthora spp. (PS), and P. capsici (PC). Limonoid 2 showed the best antifungal activity against PS (IC50 = 103.8 µg/mL) and PC (IC50 < 62.5 µg/mL) in a dose-dependent manner. While limonoid 1 exhibited a weak to moderate activity against these Phytophthora species, F. oxysporum and M. grisea were less sensitive to the two compounds tested. The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.
Triterpenoid; limonoid; trichilinin; antifungal; anti-inflammatory
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