Water-dispersible Gadolinium Oxide Nanoplates as an Effective Positive Magnetic Resonance Imaging Contrast Agent
Authors: Nguyen Thi Thuy Khue,*[a, b] Le Thi Thanh Tam,*[c] Ngo Thanh Dung,[c] Le The Tam,[d] Nguyen Xuan Chung,[e] Nguyen Thi Ngoc Linh,[f] Nguyen Dinh Vinh,[f] Bui Minh Quy,[f] and Le Trong Lu*[a, c]
: :
Publishing year: 9/2022
Gadolinium oxide (Gd2O3) nanoplates have been successfully
synthesized by thermal decomposition method in the presence
of oleic acid and oleylamine as surfactants. As a result, the
nanoplates have average edge length and thickness around
10 nm and 1.1 nm, respectively. The hydrophobic OA/OM
capped Gd2O3 nanoplates were encapsulated with amphiphilic
poly (maleic anhydride-alt-1-octadecene) polymer (PMAO) for
phase transfer into aqueous media. The obtained Gd2O3@PMAO
showed a hydrodynamic size of 32 nm with good dispersion in
water solvent and stable in wide range of pH (pH=2�11) and
at electrolyte concentrations as high as NaCl 380 mM. In
addition, the in vitro toxicity tests confirmed the biocompatibility of Gd2O3@PMAO nanoplates. The magnetic resonance
imaging (MRI) result exhibited the r1 of Gd2O3@PMAO nanoplates (16.95 mM 1s 1) is four times higher than that of
clinically used Gd-DTPA. These results suggest that the PMAO
coated -Gd2O3 nanoplates are potential T1 contrast agents for
in vivo MRI application.
Gadolinium oxide · 2D nanoplates · magnetic resonance image · contrast agent · poly (maleic anhydride-alt- 1-octadecene)
