Bài báo khoa học

Although the genus Melia of the Meliaceae family contains about five poorly defined species in the old-world tropics, almost every part of the plants of this genus are used as traditional herbal medicines, such as being anthelmintics, for the treatment of leprosy, eczema, asthma, malaria, fevers, and venereal diseases, as well as cholelithiasis, acariasis, and pain. The genus Melia is well-known as a rich and valuable source of bioactive limonoids. The genus Melia has 3 species (M. azedarach, M. dubia, and M. toosendan) in Viet Nam. Melia dubia Cav. has been shown to be a source of interesting tetranortriterpenoids. In addition, it is well known for its traditional medicinal properties and other biological activities such as insect or larval growth inhibition and as an antifeedant. Therefore, Melia dubia has been used to anti-insect and larval in agriculture in recent days. A phytochemical study from fruits of Melia dubia Cav. collected in Quy Hop, Nghe An province led to the isolation of three secondary metabolites, including 21α-O-methylmelianodiol (1), 21β-O-methylmelianodiol (2) and (21S,23R,24R)-21,23-epoxy-24-hydroxy-21β-methoxytirucalla-7,25-dien-3-one (3). The chemical structures of these compounds were determined based on 1D-, 2D- NMR, UV, IR, and MS analytical results and compared with reported data. All three compounds (1–3) were isolated from this plant for the first time.