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This paper mainly studies the quadratic growth and the strong metric subregularity of the subdifferential of a function that can be represented as the sum of a function twice differentiable in the extended sense and a subdifferentially continuous, prox-regular, twice epi-differentiable function. For such a function, which is not necessarily prox-regular, it is shown that the quadratic growth, the strong metric subregularity of the subdifferential at a local minimizer, and the positive definiteness of the subgradient graphical derivative at a stationary point are equivalent. In addition, other characterizations of the quadratic growth and the strong metric subregularity of the subdifferential are also given. Besides, properties of functions twice differentiable in the extended sense are examined.