MICROWAVE-ASSISTED CLAISEN-SCHMIDT CONDENSATION
BETWEEN ARYLMETHYL KETONES AND ARYL ALDEHYDES
CATALYZED BY CU(OTF)2 UNDER SOLVENT-FREE
CONDITIONS: SYNTHESIS OF CHALCONES
Authors: Dau Xuan Duc, Nguyen Thi Chung
Vietnam Journal of Science and Technology
: 58; 6A : 1-9
Publishing year: 9/2020
An environmentally friendly and high yield method for the Claisen-Schmidt
condensation has been investigated. A mixture of an arylmethyl ketone and an aldehyde was
irradiated in a microwave reactor for 20 minute using Cu(OTf)2 as catalyst in solvent-free
conditions. 12 chalcones were synthesized in moderate to excellent yields (74 - 91 %). This is
the first time the Claisen-Schmidt condensation with Cu(OTf)2 under microwave irradiation is
reported.
bioactivity, benzaldehyde, acetophenone, irradiation, copper triflate.
