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MICROWAVE-ASSISTED CLAISEN-SCHMIDT CONDENSATION BETWEEN ARYLMETHYL KETONES AND ARYL ALDEHYDES CATALYZED BY CU(OTF)2 UNDER SOLVENT-FREE CONDITIONS: SYNTHESIS OF CHALCONES
Authors: Dau Xuan Duc, Nguyen Thi Chung
632    37
Vietnam Journal of Science and Technology
: 58; 6A     : 1-9
: doi:10.15625/2525-2518/58/6A/15407
: 1202-clasen-schmidt.pdf
Publishing year: 9/2020
An environmentally friendly and high yield method for the Claisen-Schmidt condensation has been investigated. A mixture of an arylmethyl ketone and an aldehyde was irradiated in a microwave reactor for 20 minute using Cu(OTf)2 as catalyst in solvent-free conditions. 12 chalcones were synthesized in moderate to excellent yields (74 - 91 %). This is the first time the Claisen-Schmidt condensation with Cu(OTf)2 under microwave irradiation is reported.
bioactivity, benzaldehyde, acetophenone, irradiation, copper triflate.
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