Study on fabrication and colloidal stability of magnetic cobalt ferrite based nanofluids for magnetic resonance T2-imaging (MRI)
Authors: Le The Tam, Nguyen Thi Ngoc Linh, Nguyen Hoa Du, Phan Thi Hong Tuyet, Ho Dinh Quang, Le Thi Thu Hiep, Nguyen Thien Vuong, Le Trong Lu, Tran Dai Lam
Vietnam Journal Of Chemistry
: 57(6E1,2) : 354-360
Publishing year: 12/2019
Magnetic cobalt ferrite (CoFe2O4) nanoparticles (NPs) have been synthesized using the thermal decomposition method. The critical parameters such as surfactant concentration and OA/OLA ratio have been intensively investigated in detail to optimize conditions for the synthesis of the magnetic nanoparticles. Especially, after coating nanoparticles with the PMAO, the surface of CoFe2O4 becomes hydrophilic and well-dispersed in water. Furthermore, the obtained nanofluids are still stable over a wide range of salt concentration (from 50 to 220 mM). The spin-spin (T2) relaxation times of the nuclear spins (hydrogen protons) in aqueous solutions of various concentrations of coated ferrite nanoparticles were determined using a nuclear magnetic resonance (NMR) spectrometer. The MRI image was detected with higher contrast in comparison with the control sample. The MRI images of in-vitro samples taken by the T2 status which shows that our coated ferrite nanoparticles can be used as a T2 MRI contrast agent. These findings suggest the potential application of PMAO-coated magnetic CoFe2O4 NPs in the biomedical discipline
