Tinh dầu thân rễ của cây họ gừng (Meistera verrucosa) từ tỉnh Hà Giang, Việt Nam: Thành phần hóa học, hoạt tính chống oxy hóa và nghiên cứu docking phân tử
Tác giả: Dinh Thi Truong Giang, Hieu Tran Trung, Nguyen Hoang Tuan, Nguyen Xuan Ha, Dang Khoa Nguyen, Minh Chanh Nguyen, Nguyen Thi Thu Hien, Vi Thi Thuan, Tran Thi Thu Hang, Ngu Thi Tra Giang & Hoang Van Trung,
Journal of Essential Oil Bearing Plants
Quyển: 5/27 Trang: 1439 – 1448
Năm xuất bản: 11/2024
Tóm tắt
This work aimed to determine the chemical composition and antioxidant
activity of rhizome essential oil (EO) of Meistera verrucosa growing wild in
Ha Giang Province, Vietnam. The EO was isolated using hydrodistillation,
then the chemical composition was analyzed by Gas chromatographymass spectroscopy (GC-MS). In addition, the antioxidant activities were
determined by the DPPH scavenging method and ferric reducing antioxidant
power (FRAP) assay. The results showed that α-pinene, β-pinene, and
(E)-β-ocimene were major components in the EO, accounting for 39.6%,
20.7%, and 12.2%, respectively. The EO showed antioxidant activity, the
IC
50 value of DPPH scavenging activity, and the EC50 value of FRAP assay
were 91.01 mg/mL and 17.50 mg/mL, respectively. Furthermore, to evaluate
the inhibitory interaction potential of Keap1, docking analysis indicated that
α-pinene has the strongest affinity among the major compounds surveyed.
The key interactions observed in the complexes of the major compounds
with Keap1 are predominantly hydrophobic interactions (pi-sigma and pialkyl), which significantly contribute to their binding affinities. These results
provide more information on the volatile compounds of the EO from the
rhizomes of M. verrucosa and first reveal its antioxidant power.
Từ khóa
Meistera verrucosa, Essential oil, Phytochemical composition, Antioxidant activity, Molecular docking